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My arm hurts...

Travel Forums Off Topic My arm hurts...

1. Posted by GregW (Travel Guru 2635 posts) 11y

Got the last of my Twinrex shots today to protect (apparently for LIFE) against Hep A and Hep B. Started the treatment about 8 weeks prior to going to Africa.

I'm a little sad because today was just a reminder that Africa is behind me. I miss the anticipation of going....

  • sigh*
2. Posted by Cupcake (Travel Guru 8468 posts) 11y

Don't shoot the messanger! But when you get checked at the 24 and 48 month mark (to be sure of immunization) You may need a booster:(
They also haven't determined if or when boosters will be needed :(

3. Posted by Travel100 (Travel Guru 1556 posts) 11y

Quoting CupCake

Don't shoot the messanger! But when you get checked at the 24 and 48 month mark (to be sure of immunization) You may need a booster:(
They also haven't determined if or when boosters will be needed :(

I got the shots for life time Hep-A immunity. Never knew about a 24 or 48 month check up. Is that just for Hep-B?

4. Posted by Cupcake (Travel Guru 8468 posts) 11y

Well, I know in Michigan and Arizona they do a 24-48 month check up to make sure you have the antibodies. I am not sure if it is a national requirment? Especially if you have the 'express' shots (the 7,14, 21 day schedule, for people who would be travlling sooner)

5. Posted by Travel100 (Travel Guru 1556 posts) 11y

I did it a while ago. They weren't express shots. I think it was 6-12 months after the first couple shots that I got the final booster. At least I thought it was Final :( .

6. Posted by GregW (Travel Guru 2635 posts) 11y

They never mentioned anything about a check after the final shot. Must just be a Michigan thing.

7. Posted by Cupcake (Travel Guru 8468 posts) 11y

I hope so! For everyones sake! :)

8. Posted by Travel100 (Travel Guru 1556 posts) 11y

gosh Cupcake...you're causing panic among the "lifetime" immune travelers...

9. Posted by abcdf (Full Member 557 posts) 11y

Thanks GregW. That reminds me of getting my last hep a/b shot. Man, those shots are a pain... or maybe its the big nurse who slaps the needle into your arm, just to make it extra painful *wince*.

10. Posted by Cupcake (Travel Guru 8468 posts) 11y

This was all I could find on a quick search...I will talk to a few doctor friends next week and let you know.....

- Primary vaccination schedule

The standard primary course of vaccination with Twinrix Adult consists of three doses, the first administered at the elected date, the second one month later and the third six months after the first dose.

In exceptional circumstances in adults, when travel is anticipated within one month or more after initiating the vaccination course, but where insufficient time is available to allow the standard 0, 1, 6 month schedule to be completed, a schedule of three intramuscular injections given at 0, 7 and 21 days may be used. When this schedule is applied, a fourth dose is recommended 12 months after the first dose.

The recommended schedule should be adhered to. Once initiated, the primary course of vaccination should be completed with the same vaccine.

- Booster dose

Long-term antibody persistence data following vaccination with TWINRIX Adult are available up to 60 months after vaccination. The anti-HBs and anti-HAV antibody titres observed following a primary vaccination course with the combined vaccine are in the range of what is seen following vaccination with the monovalent vaccines. The kinetics of antibody decline are also similar. General guidelines for booster vaccination can therefore be drawn from experience with the monovalent vaccines.

Hepatitis B

The need for a booster dose of hepatitis B vaccine in healthy individuals who have received a full primary vaccination course has not been established; however some official vaccination programmes currently include a recommendation for a booster dose of hepatitis B vaccine and these should be respected.

For some categories of subjects or patients exposed to HBV (e.g. haemodialysis or immunocompromised patients) a precautionary attitude should be considered to ensure a protective antibody level GREATER-THAN OR EQUAL TO (8805) 10IU/l.

Hepatitis A

It is not yet fully established whether immunocompetent individuals who have responded to hepatitis A vaccination will require booster doses as protection in the absence of detectable antibodies may be ensured by immunological memory. Guidelines for boosting are based on the assumption that antibodies are required for protection; anti-HAV antibodies have been predicted to persist for at least 10 years.

In situations where a booster dose of both hepatitis A and hepatitis B are desired, Twinrix Adult can be given. Alternatively, subjects primed with Twinrix Adult may be administered a booster dose of either of the monovalent vaccines.